Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effect of cycloserine combined with anti-tuberculosis drugs in the treatment of multidrug-resistant tuberculosis

Yang Zhao¹, Mabin Si¹, Zhihui Li², Xiulei Yu³ ,

¹Department of Radiology; ²Department of ICU; ³Department of Ultrasonography, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 Huancheng Road East, Hangzhou, Zhejiang Province, China.

For correspondence:- Xiulei Yu Email: xiuleiyu@163.com

Accepted: 16 January 2021 Published: 28 February 2021

Citation: Zhao Y, Si M, Li Z, Yu X, Therapeutic effect of cycloserine combined with anti-tuberculosis drugs in the treatment of multidrug-resistant tuberculosis. Trop J Pharm Res 2021; 20(2):419-424 doi: 10.4314/tjpr.v20i2.28

© 2021 The authors.
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Abstract

Purpose: The present study analyzes the comprehensive therapeutic effect of cycloserine, in combination with anti-tuberculosis drugs using chest X-ray and chest CT (computed tomography) scan techniques.

Methods: A total of 90 patients, diagnosed with multidrug resistant tuberculosis (MDR TB) were subjected to chest x-ray and CT scan before and after treatment in the two groups. Different views such as sagittal, coronal, lung window and multiplanar imaging of mediastinal window were taken. Some parameters such as case detection rate (CDR) in chest X-ray and CT scan and comprehensive curative effect were observed in two groups. Further, the changes in chest CT signs in addition to absorption of focus, cavity closure and changes in CT extra pulmonary signs were also observed.

Results: The clinical profile of the patients and the course of disease were statistically insignificant (p > 0.05). Total effectiveness rate and case detection rate (CDR) values exhibited a significant difference between the groups (p < 0.05). Lung consolidation, nodules and cavities significantly improved in both groups before and after the treatment (p < 0.05). Both groups showed significant improvements in extrapulmonary signs in CT scan (p < 0.05) after the treatment.

Conclusion: Based on the study outcomes, the CT scan method has good potentials for diagnosing and treating MDR TB at the early stages. Further, it can clarify the signs and outcomes of the disease at early stages, thus providing the medical fraternity a great opportunity to cure the disease.

Keywords: CT scan, Cycloserine, Anti-tuberculosis treatment, Multidrug-resistant tuberculosis, Efficacy assessment